The square contains a bronze statue by Marshall Daugherty honoring John Wesley, founder of Methodism. Wesley spent most of his life in England but undertook a mission to Savannah (1735–1738), during which time he founded the first Sunday school in America. The statue was installed in 1969 on the spot where Wesley's home is believed to have stood. The statue is intended to show Wesley preaching out-of-doors as he did when leading services for Native Americans, a practice which angered church elders who believed that the Gospel should only be preached inside the church building.
Reynolds Square was the site of the Filature, which housed silkworms as part of an early—and unsuccessful—attempt to establish a silk industry in the Georgia colony. It is located on Abercorn, between Bryan and Congress Streets.