From early colonial days through the 19th century the road was known as Harlem Lane. It is claimed to have followed an old Indian path called Weekquaeskeek. The road accommodated travelers going toward Spuyten Duyvil, Kingsbridge, and points north. Harlem Lane was sometimes referred to as the Kingsbridge Road, and it constituted a portion of the old Post Road that led from lower Manhattan to New England. St. Nicholas Avenue is named after Saint Nicholas of Myra, patron saint of New Amsterdam since Dutch times.